Work

Hydrogen Peroxide Triggered Prochelator Activation, Subsequent Metal Chelation, and Attenuation of the Fenton Reaction

Year: 2007

Type: article

Abstract: Fenton antidote: The prochelator 2-boronobenzaldehyde isonicotinoyl hydrazone (SIH-B) reacts with H2O2 to yield the active chelator salicylaldehyde isonicotinoyl hydrazone (SIH), which sequesters copper and iron ions (see scheme; M=Fe, Cu). This process attenuates both Fe- and Cu-promoted Fenton reactions under physiologically relevant conditions.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200604859

Authors: Yibin Wei, Maolin Guo

Institution: University of Massachusetts Dartmouth

Language: English

Topic: Free Radicals and Antioxidants

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Center for Complementary and Integrative Health

Award: Role of iron homeostasis in cranberry's bio-effects