Neural cell cycle dysregulation and central nervous system diseases: role of Cdk1
Year: 2015
Type: article
Abstract: Event Abstract Back to Event Neural cell cycle dysregulation and central nervous system diseases: role of Cdk1 Quentin Marlier1*, Renaud Vandenbosch1, Nicolas Caron2, Philipp Kaldis3, Laurent Nguyen1 and Brigitte Malgrange1 1 GIGA Neurosciences-University of Liege, Belgium 2 Affichem, France 3 Institute of Molecular and Cell Biology, Department of Biochemistry, Singapore Age-related neurological disorders, including stroke and neurodegenerative diseases, are becoming a major health care problem in many countries as average life expectancy is increasing. Neuronal death is indeed the common point between these diseases and will lead to symptomatology. Two therapeutic approaches can be considered: firstly, the prevention or cessation of programmed cell death and secondly, the replacement of lost neurons thanks to the recruitment of endogenous neural stem cells present in two specific areas of the central nervous system (CNS), the adult dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles (B). Both strategies share a common molecular mechanism: the cell cycle. This work focus on the cyclin dependant kinase 1 (Cdk1), a major regulator of the cell cycle Keywords: Cdk1, adult neurogenesis, proliferation, Cell Death, Stroke Conference: 11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium, 22 May - 22 May, 2015. Presentation Type: Poster presentation Topic: Neuroscience Citation: Marlier Q, Vandenbosch R, Caron N, Kaldis P, Nguyen L and Malgrange B (2015). Neural cell cycle dysregulation and central nervous system diseases: role of Cdk1. Front. Neurosci. Conference Abstract: 11th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2015.89.00025 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 May 2015; Published Online: 05 May 2015. * Correspondence: PhD. Quentin Marlier, GIGA Neurosciences-University of Liege, Liège, 4000, Belgium, [email protected] Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Quentin Marlier Renaud Vandenbosch Nicolas Caron Philipp Kaldis Laurent Nguyen Brigitte Malgrange Google Quentin Marlier Renaud Vandenbosch Nicolas Caron Philipp Kaldis Laurent Nguyen Brigitte Malgrange Google Scholar Quentin Marlier Renaud Vandenbosch Nicolas Caron Philipp Kaldis Laurent Nguyen Brigitte Malgrange PubMed Quentin Marlier Renaud Vandenbosch Nicolas Caron Philipp Kaldis Laurent Nguyen Brigitte Malgrange Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
Source: Frontiers in Neuroscience
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4256320438