Work

Endometrial cell specific gene activation during implantation and early pregnancy

Year: 2002

Type: review

Abstract: Human endometrium expresses numerous genes to achieve an optimal uterine environment for implantation and maintaining the pregnancy. In this review, we will summarize our previous observations on progestin regulated gene expression, estrogen metabolic enzymes, nitric oxide synthase, aromatase, IGF-I and II, IGFBP-1, prolactin and glycodelin. These genes are differentially activated in two types of endometrial cells during the menstrual cycle and early pregnancy. Multiple gene activation driven by progestin appears to be the major event responsible for the differentiation of endometrial cells. They play critical roles of endometrial cell function during implantation and pregnancy.

Source: Frontiers in bioscience

DOI: 10.2741/a861

Author: Linda Tseng

Institutions: State University of New York, Stony Brook University

Language: English

Topic: Reproductive System and Pregnancy

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: State University of New York, National Institutes of Health, U.S. Public Health Service, Eunice Kennedy Shriver National Institute of Child Health and Human Development