Future Surgical Therapies in Parkinson's Disease
Year: 2003
Type: book-chapter
Abstract: The resurgence of neurosurgical therapies in Parkinson’s disease (PD), and movement disorders in general, is largely due to advances in transplant neurobiology and basal ganglia physiology. Developments in molecular biology, combined with growing insight into the pathogenesis of movement disorders, anticipate new rational treatments not only for PD but also for many other disorders unresponsive to traditional therapies. This chapter will focus on two of the most promising therapeutic approaches: gene therapy and cell-transplant therapy. Advances in gene-therapy methods over the past decades show promising vectors that are capable of long-term transgene expression without producing toxicity. Novel neuronal cell lines with desired phenotypes may circumvent many of the limitations of primary neuronal cell transplantation. The traditional concept of neural cells being terminally differentiated has been challenged by discoveries of multipotent and self-renewing neuronal stem cells. Using these approaches, one can not only enhance symptomatic therapy but also attempt neuroprotective therapy. The examples will be primarily illustrated in experimental studies of PD.
Source: Humana Press eBooks
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2265279346