Tumor-stromal interactions assessed by co-injection of pancreatic stellate and cancer cells
Year: 2011
Type: dataset
Abstract: Over the past several decades, the importance of the stroma to cancer progression has become increasingly recognized. Rather than existing in isolation, cancer cells are surrounded by a tumor microenvironment that is largely the product of pancreatic stellate cells (PSC) that are sometimes referred to as stromal or cancer-associated fibroblasts. The tumor microenvironment also includes other cells such as immune cells and adipocytes as well as vascular and lymphatic networks and prominent extracellular matrix. In both chronic pancreatitis and in pancreatic adenocarcinoma (PAC) the stroma is problematic because it is quite extensive. In particular, the desmoplastic nature of PAC contributes to the limited surgical options for most patients at the time of diagnosis. Furthermore, recent evidence indicates that in PAC the stroma influences chemoresistance and metastasis.(2, 5)
DOI: 10.3998/panc.2011.32
Author: Rosa F. Hwang
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W427389120