Work

Studies on the Transmission of a Tigecycline Resistance-Mediating tet (A) Gene Variant from Enterobacter hormaechei via a Two-Step Recombination Process

Year: 2022

Type: article

Abstract: Tigecycline is an important last-resort broad spectrum antimicrobial agent. This study describes the two-step recombination processes resulting in the transfer of the tet (A) variant gene between different plasmids in E. hormaechei , which depicts the role of recombination processes in the generation of UCSs and new plasmids, both carrying a tet (A) variant conferring resistance to tigecycline.

Source: Microbiology Spectrum

DOI: 10.1128/spectrum.00496-22

Authors: Runhao Yu, Zheng Chen, Danyang Li, Stefan Schwarz, Xinwei Wang, Xiang-Dang Du

Institutions: Henan Agricultural University, Freie Universität Berlin

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500