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Alzheimer’s Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects—Atherosclerosis for a Start

Year: 2022

Type: article

Abstract: Three decades with the amyloid hypothesis, nearly two with amyloid-PET imaging, and one with testing of anti-amyloid therapy have not yielded benefits to patients with Alzheimer's disease (AD). It is time to focus on more promising options, e.g., infection, low dose radiation, and atherosclerosis. The relevance of the latter in managing AD has fluctuated from being significant to insignificant. Current methodologies for detecting cerebral atherosclerosis reflect advanced changes in only major arteries. In contrast, 18F-sodium fluoride PET imaging assessing early-stage cerebral atherosclerosis regionally or in the entire vascular bed may provide new insight in this age-related process in dementia.

Source: Journal of Alzheimer s Disease

DOI: 10.3233/jad-220190

Authors: Poul F. Høilund-Carlsen, Mona-Elisabeth Revheim, Abass Alavi

Institutions: University of Southern Denmark, Odense University Hospital, Oslo University Hospital, University of Oslo, Hospital of the University of Pennsylvania

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4280534172

FWCI: 1.141

Cites: 27

Cited by: 10

Related to: 10