Work

Experimental Hybridization in Leishmania: Tools for the Study of Genetic Exchange

Year: 2022

Type: review

Abstract: Despite major advances over the last decade in our understanding of Leishmania reproductive strategies, the sexual cycle in Leishmania has defied direct observation and remains poorly investigated due to experimental constraints. Here, we summarize the findings and conclusions drawn from genetic analysis of experimental hybrids generated in sand flies and highlight the recent advances in generating hybrids in vitro. The ability to hybridize between culture forms of different species and strains of Leishmania should invite more intensive investigation of the mechanisms underlying genetic exchange and provide a rich source of recombinant parasites for future genetic analyses.

Source: Pathogens

DOI: 10.3390/pathogens11050580

Authors: Tiago R. Ferreira, David L. Sacks

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Research on Leishmaniasis Studies

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $2,303

Funder: National Institutes of Health