Stability of SARS-CoV-2-Encoded Proteins and Their Antibody Levels Correlate with Interleukin 6 in COVID-19 Patients
Year: 2022
Type: article
Abstract: SARS-CoV-2, the etiological cause of COVID-19, carries 29 genes in its genome. However, our knowledge of the viral proteins in biological and biochemical aspects is limited. In this study, we globally profiled the stability of the viral proteins in living lung epithelial cells. Importantly, the labile SARS-CoV-2-encoded proteins were mainly degraded through the ubiquitin-proteasome pathway. Stable proteins, including spike and nucleocapsid, of SARS-CoV-2 were more effective in eliciting antibody production. The levels of antiviral antibodies targeting NSP10 were negatively correlated with systemic levels of IL-6 in COVID-19 patients.
Source: mSystems
Institutions: University of Pittsburgh, Tulane University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,500
Awards: G1000903745, G170835177, G1909988890, Microbiome-based diagnosis of pneumonia in the acute respiratory distress syndrome, Pathogenesis of Obstruction/Emphysema and the Microbiome (POEM) in HIV, G2587690447, G4227803264, Epigenetic Modulation in Septic Immunosuppression, Patient-Oriented Research in Acute Lung Injury and Host Defense in the ICU, Mechanisms of host protection against pathogen-associated proteases in acute lung injury, G6759330711, Generation and Characterization of a Novel Cell Subpopulation Ablation Model, Mentoring and Patient-Oriented Research in HIV Obstructive Lung Disease, G7862536988, Immunosuppression in Acute Lung Injury, Host control mechanisms against K. pneumoniae infection in the lungs, G8902106809, Tulane National Primate Research Center
OpenAlex ID: W4280576905