Protein control of membrane and organelle dynamics: Insights from the divergent eukaryote Toxoplasma gondii
Year: 2022
Type: review
Abstract: Integral membrane protein complexes control key cellular functions in eukaryotes by defining membrane-bound spaces within organelles and mediating inter-organelles contacts. Despite the critical role of membrane complexes in cell biology, most of our knowledge is from a handful of model systems, primarily yeast and mammals, while a full functional and evolutionary understanding remains incomplete without the perspective from a broad range of divergent organisms. Apicomplexan parasites are single-cell eukaryotes whose survival depends on organelle compartmentalisation and communication. Studies of a model apicomplexan, Toxoplasma gondii, reveal unexpected divergence in the composition and function of complexes previously considered broadly conserved, such as the mitochondrial ATP synthase and the tethers mediating ER-mitochondria membrane contact sites. Thus, Toxoplasma joins the repertoire of divergent model eukaryotes whose research completes our understanding of fundamental cell biology.
Source: Current Opinion in Cell Biology
Institutions: University of Glasgow, Indiana University School of Medicine
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,530
Awards: Regulation of mitochondrial morphodynamics in Toxoplasma gondii, G2618575860, Lost in translation. Dissecting the divergent features of Toxoplasma gondii mitochondrial translation, Interleukin-1 and Steroid Signaling Drive Toxoplasma-induced Prostatic Hyperplasia, Lost in translation. Dissecting the divergent features of Toxoplasma gondii mitochondrial translation
OpenAlex ID: W4280598611