Work

Hostile Takeover: Tregs Expand in IFNγ-Rich AML Microenvironment

Year: 2022

Type: editorial

Abstract: The unexpected higher level of IFNγ in a subset of patients with acute myeloid leukemia (AML; IFNγhigh) upregulates immunosuppressive genes in mesenchymal stem cells (MSC) and expands regulatory T cells through IDO1 overexpression. IDO1 and IFNG gene expression was positively correlated and required both leukemia cells and MSCs, as IFNγhigh cells were not able to induce Tregs alone. See related article by Corradi et al., p. 3141.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-22-1030

Authors: P. Brent Ferrell, Shahram Kordasti

Institutions: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, King's College London

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Celgene