Work

Cell cycle and developmental control of cortical excitability in Xenopus laevis

Year: 2022

Type: article

Abstract: Here we combine imaging with computational analysis to describe previously unnoticed changes in cortical excitability that respond to both cell cycle and developmental state. We also report two spatially segregated populations of waves: pan-cortical waves that are present throughout the cell cycle and F-actin waves confined to the cleavage furrow.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.e22-01-0025

Authors: Zachary T. Swider, Ani Michaud, Marcin Leda, Jennifer Landino, Andrew B. Goryachev, William M. Bement

Institutions: University of Wisconsin–Madison, University of Edinburgh, University of Michigan

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, Biotechnology and Biological Sciences Research Council, National Institute of General Medical Sciences

Awards: Cortical excitability as a mechanism for epithelial barrier maintenance: A joint experiment-theory systems approach, 20-BBSRC/NSF-BIO: Synthetic Control of Pattern Formation and Morphogenesis in a Purposefully Rewired Vertebrate Cell, Bilateral BBSRC-NSF/BIO: Excitocell: A rewired eukaryotic cell model for the analysis and design of cellular morphogenesis, Dynamic Pattern Formation in the Cell Cortex, 15 NSFBIO: Excitocell: A rewired eukaryotic cell model for the analysis and design of cellular morphogenesis