Network-specific selectivity of functional connections in the neonatal brain
Year: 2022
Type: article
Study design: Observational Study
Abstract: The adult human brain is organized into functional brain networks, groups of functionally connected segregated brain regions. A key feature of adult functional networks is long-range selectivity, the property that spatially distant regions from the same network have higher functional connectivity than spatially distant regions from different networks. Although it is critical to establish the status of functional networks and long-range selectivity during the neonatal period as a foundation for typical and atypical brain development, prior work in this area has been mixed. Although some studies report distributed adult-like networks, other studies suggest that neonatal networks are immature and consist primarily of spatially isolated regions. Using a large sample of neonates (n = 262), we demonstrate that neonates have long-range selective functional connections for the default mode, fronto-parietal, and dorsal attention networks. An adult-like pattern of functional brain networks is evident in neonates when network-detection algorithms are tuned to these long-range connections, when using surface-based registration (versus volume-based registration), and as per-subject data quantity increases. These results help clarify factors that have led to prior mixed results, establish that key adult-like functional network features are evident in neonates, and provide a foundation for studies of typical and atypical brain development.
Source: Cerebral Cortex
Authors: Chad M Sylvester, Sydney Kaplan, Michael J Myers, Evan M Gordon, Rebecca F Schwarzlose, Dimitrios Alexopoulos, Ashley N Nielsen, Jeanette K Kenley, Dominique Meyer, Qiongru Yu, Alice M Graham, Damien A Fair, Barbara B Warner, Deanna M Barch, Cynthia E Rogers, Joan L Luby, Steven E Petersen, Christopher D Smyser
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: ATTENTION AND RELATED FUNCTIONAL BRAIN NETWORKS IN PEDIATRIC ANXIETY DISORDERS, Brain trajectories in ADHD, Prevention Research Center: Parenting Among Women Who Are Opioid Users, Washington University Intellectual and Developmental Disabilities Research Center, THE PRETERM BEHAVIORAL PHENOTYPE: TRAJECTORIES OF PSYCHOPATHOLOGY & CHANGES IN CEREBRAL CONNECTIVITY, Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASD, PREDICTING CHILDHOOD OUTCOMES IN PRETERM INFANTS USING CEREBRAL CONNECTIVITY, PREDICTING PRESCHOOL PSYCHOPATHOLOGY WITH BRAIN CONNECTIVITY IN PRETERM NEONATES, 1/4 Investigation of opioid exposure and neurodevelopment (iOPEN), Common Mechanisms linking Pre- and Post-Natal Exposures for Child Health Outcomes, 12/24 Healthy Brain and Child Development National Consortium, Developmental Pathways to Borderline Personality Disorder: Longitudinal Observational, Clinical, and Neural Predictors From Early Childhood to Young Adulthood, Longitudinal Development of Attention-Related Brain Networks from Birth to School-Age and Risk for Anxiety Disorders, Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental Disorders
OpenAlex ID: W4281263921