Year: 2022
Type: review
Abstract: Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation and iron overload, which is different from other types of programmed cell death, including apoptosis, necroptosis, autophagy, and pyroptosis. Over the past years, emerging studies have shown a close relation between ferroptosis and various cardiovascular diseases such as atherosclerosis, acute myocardial infarction, ischemia/reperfusion injury, cardiomyopathy, and heart failure. Herein, we will review the contributions of ferroptosis to multiple cardiovascular diseases and the related targets. Further, we discuss the potential ferroptosis-targeting strategies for treating different cardiovascular diseases.
Authors: Yuting Guo, Wei Zhang, Xinger Zhou, Shihao Zhao, Jian Wang, Yi Guo, Yichao Liao, Haihui Lu, Jie Liu, Yanbin Cai, Jiao Wu, Mingzhi Shen
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,490
Awards: G2360091098, G7320523754
OpenAlex ID: W4281291527