Year: 2022
Type: review
Abstract: Aging is characterized by progressive functional declines at the organismal, organic, and cellular levels and increased susceptibility to aging-related diseases. Epigenetic alteration is a hallmark of aging, senescent cells show epigenomic changes at multiple scales, such as 3D genome reorganization, alterations of histone modifications and chromatin accessibility, and DNA hypomethylation. Chromosome conformation capture (3C)-based technologies have enabled the generation of key information on genomic reorganizations during senescence. A comprehensive understanding of epigenomic alterations during aging will yield important insights into the underlying epigenetic mechanism for aging regulation, the identification of aging-related biomarkers, and the development of potential aging intervention targets.
Source: Cell Insight
Institutions: Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Stem Cell and Reproductive Biology, State Key Laboratory of Membrane Biology, Beijing Institute for Stem Cell and Regenerative Medicine, Salk Institute for Biological Studies, Beijing Institute of Genomics, Capital Medical University, Xuan Wu Hospital of the Capital Medical University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,950
Funders: Tencent, Moxie Foundation, Milky Way Research Foundation, National Natural Science Foundation of China, Chinese Academy of Sciences, Ministry of Science and Technology of the People's Republic of China, Natural Science Foundation of Beijing Municipality, National Key Research and Development Program of China
Awards: G1087497514, G1117754195, G1187093019, G1500470957, G1825275149, G2045722200, G2149619913, G2874098611, G3088791492, G3150443997, G3713094572, G4264198362, G4491697950, G453067906, G6072460052, G6255687796, G6684708555, G6790151920, G6844520676, G6959441181, G7554964200, G7747176477, G7819028244, G7863014348, G793329496, G824452537, G8265315788
OpenAlex ID: W4281560171