Year: 2022
Type: review
Abstract: Thy-1 is a cell surface glycosylphosphatidylinositol (GPI)-anchored glycoprotein that bears a broad mosaic of biological roles across various cell types. Thy-1 displays strong physiological and pathological implications in development, cancer, immunity, and tissue fibrosis. Quite uniquely, Thy-1 is capable of mediating integrin-related signaling through directtrans-andcis-interaction with integrins. Both interaction types have shown distinctive roles, even when interacting with the same type of integrin, where binding intransor incisoften yields divergent signaling events. In this review, we will revisit recent progress and discoveries of Thy-1–integrin interactions intransand incis, highlight their pathophysiological consequences and explore other potential binding partners of Thy-1 within the integrin regulation/signaling paradigm.
Authors: Ping Hu, Lisette Leyton, James S. Hagood, Thomas H. Barker
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: MECHANISMS TRIGGERING AVB3 INTEGRIN EXPRESSION IN ASTROCYTE REACTIVITY, G3180033168, G5520316217, Platelet-like particles for augmenting hemostasis, G5876182756, G652983587, CAVEOLIN-1-INDUCED CHANGES IN CANCER CELL METABOLISM AND EXOSOME COMPOSITION AS MEDIATORS OF M2 MACROPHAGE POLARIZATION TO PROMOTE TUMOR ANGIOGENESIS, CENTRO DE ESTUDIOS AVANZADOS DE ENFERMEDADES CRONICAS (ACCDIS), PHOSPHATASES AND EXOSOMES IN CAVEOLIN-1-MEDIATED METASTASIS, G99091514
OpenAlex ID: W4281640384