Work

The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells

Year: 2022

Type: review

Abstract: Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells that mediate their functions. Integrins are usually in a resting state in blood cells until agonist stimulation results in a high-affinity conformation ("integrin activation"), which is central to integrins' contribution to blood cells' trafficking and functions. In this review, we summarize the mechanisms of integrin activation in blood cells with a focus on recent advances understanding of mechanisms whereby Rap1 regulates talin1-integrin interaction to trigger integrin activation in lymphocytes, platelets, and neutrophils.

Source: Frontiers in Cell and Developmental Biology

DOI: 10.3389/fcell.2022.908622

Authors: Hao Sun, Frederic Lagarrigue, Mark H. Ginsberg

Institutions: University of California San Diego, Centre National de la Recherche Scientifique, Université Toulouse III - Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950