Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty
Year: 2022
Type: review
Abstract: Tissue-resident memory T cells (TRM) represent a subset of antigen-experienced T cells that are constantly retained in a given tissue with limited trafficking through the circulation. These cells are characterized by expression of molecules enabling their tissue anchoring and downregulation of molecules promoting tissue egress. They reside at sites of previous antigen encounter and their number increases with age. TRM have been shown to provide rapid and efficient protection against tissue reinfection and TRM density correlates with efficient antitumor responses. Intriguingly, the density of CD8 TRM is increased in the central nervous system (CNS) of patients with neuroinflammatory diseases such as multiple sclerosis, or suffering from neurodegenerative diseases. In this review, we discuss current knowledge regarding the diversity of CNS-resident CD8 T cells and their role in CNS autoimmunity. Given their likely contribution to the protracted course of several inflammatory diseases of the CNS, their therapeutic targeting becomes an important challenge.
Source: Current Opinion in Immunology
Institutions: University of Geneva, University Hospital of Geneva, Centre National de la Recherche Scientifique, Inserm, Institut Toulousain des Maladies Infectieuses et Inflammatoires, Université de Toulouse, Centre Hospitalier Universitaire de Toulouse, Hôpital Purpan, Hôpital Paule de Viguier, Hôpital de La Grave
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,460
Awards: Drivers and signatures of neuronal dysfunction in neuroinflammation, G6287040515, Molecular pathology of anti-viral T cell responses in the central nervous system, Biomarkers in autoimmune EncephaliTis and Paraneoplastic neurological SYndromes, Deciphering transcriptional regulators of T cell fate decisions in CNS autoimmunity, G8967381738
OpenAlex ID: W4281664196