Work

Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity

Year: 2022

Type: article

Abstract: In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal ( B. cinereal ), Botryosphaeria dothidea ( B. dothidea ), and Phomopsis sp. were determined using the poison plate technique. Biological test results showed that compound 6h revealed lower EC 50 values (25.9 and 50.8 μg/ml) on Phompsis sp. than those of pyrimethanil (32.1 and 62.8 μg/ml).

Source: Frontiers in Chemistry

DOI: 10.3389/fchem.2022.922813

Authors: Nianjuan Pan, Chunyi Liu, Ruirui Wu, Qiang Fei, Wenneng Wu

Institution: Guiyang University

Language: English

Topic: Fungal Plant Pathogen Control

Subfield: Ecology, Evolution, Behavior and Systematics

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,950

Funder: Guiyang University