New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021
Year: 2022
Type: article
Abstract: Clinical and molecular heterogeneity are common features of human disease. Understanding the basis for heterogeneity has led to major advances in therapy for many cancers and pulmonary diseases such as cystic fibrosis and asthma. Although heterogeneity of risk factors, disease severity, and outcomes in survivors are common features of the acute respiratory distress syndrome (ARDS), many challenges exist in understanding the clinical and molecular basis for disease heterogeneity and using heterogeneity to tailor therapy for individual patients. This report summarizes the proceedings of the 2021 Aspen Lung Conference, which was organized to review key issues related to understanding clinical and molecular heterogeneity in ARDS. The goals were to review new information about ARDS phenotypes, to explore multicellular and multisystem mechanisms responsible for heterogeneity, and to review how best to account for clinical and molecular heterogeneity in clinical trial design and assessment of outcomes. The report concludes with recommendations for future research to understand the clinical and basic mechanisms underlying heterogeneity in ARDS to advance the development of new treatments for this life-threatening critical illness.
Institutions: University of Washington, University of Michigan, Michigan Medicine, Vanderbilt University, Vanderbilt University Medical Center, University of Colorado Anschutz, University of Colorado Denver, National Jewish Health, Stanford Medicine, Stanford University, Universities of Giessen and Marburg Lung Center, Cardio-Pulmonary Institute, Oregon Health & Science University, University of California, San Francisco, University of Pennsylvania, Beth Israel Deaconess Medical Center, Harvard University, Center for Vascular Biology Research, The University of Texas Southwestern Medical Center, University of South Alabama, Massachusetts General Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Defense, U.S. Department of Veterans Affairs, Deutsche Forschungsgemeinschaft, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, U.S. National Library of Medicine
Awards: G1060998659, Mentored Patient Oriented Research in ARDS and Critical Illness Outcomes, G1223096295, Tie2-driven vascular control in critical illness, G1337243466, G13806056, Effect of randomization to neuromuscular blockade on physical functional impairment and recovery in ARDS, Lung endothelial cell phenotypes, G2109155418, Reconsidering the IL-1 axis in sepsis-associated ARDS, CCC for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL Network, G2278034129, G254920692, G2676724552, G270668470, Midcareer Investigator Award in Patient-Oriented Research in Acute Lung Injury, G3017246272, Role of TGFβ/BMP Antagonism in Regeneration of the Alveolar Epithelium After Lung Injury, G3422402278, G3476680778, G3819315772, G3983903862, ARDS in the 21st Century: New Insights into Clinical and Mechanistic Heterogeneity, G4553316662, G4630974692, G4655817489, Albumin Nanoparticles Incorporating Piceatannol (PANPs) for ALI/ARDS therapy, G502689736, Haptoglobin 2 variant and endothelial glycocalyx shedding in sepsis-induced ARDS, HLS13-13 Albumin nanoparticle based technology to treat ARDS, G5972088883, G602599608, Mechanisms of Repair of the Alveolar Epithelium after Lung Injury, Targeting Angiopoietin-2 in ARDS, Beyond PheWAS: Recognition of Phenotype Patterns for Discovery and Translation, G6608807841, Targeting circulating endothelial glycocalyx fragments to reduce septic encephalopathy, Angiopoietin/Tie signaling regulation of vascular leakage in lung inflammation, G7147832242, Targeting cell-free hemoglobin in sepsis to reduce lung microvascular permeability: mechanistic and translational studies, G7311292982, Role of FXR and TGR5 in Age Related Renal Diseases, Precision Medicine in the Acute Respiratory Distress Syndrome, Mentoring Patient-Oriented Research to Promote ARDS Precision Medicine, The GOLD Study: Goal of Open Lung Ventilation in Donors, G8063312293, G8083453391, Identifying niche factors regulating distinct properties of AT2 stem cells, G8219381154, Lung Endothelial Aß in infectious proteinopathy, G8556351262, Fibroblast Resistance to Apoptosis in Pulmonary Fibrosis, Immunomodulation by splenic megakaryocytes and platelets in sepsis, Mechanisms and pathogenicity of SARS-CoV-2-induced neutrophil extracellular traps, Nosocomial pneumonias impair cognitive function, Immunobiology of the normal and injured lung, Novel exosomal niches for alveolar stem cell-bassed repair of ARDS, G97300172
OpenAlex ID: W4281667251