Work

The DUX4 protein is a co‐repressor of the progesterone and glucocorticoid nuclear receptors

Year: 2022

Type: article

Abstract: DUX4 is a transcription factor required during early embryonic development in placental mammals. In this work, we provide evidence that DUX4 is a co-repressor of nuclear receptors (NRs) of progesterone (PR) and glucocorticoids (GR). The DUX4 C-ter and N-ter regions, including the nuclear localization signals and homeodomain motifs, contribute to the co-repressor activity of DUX4 on PR and GR. Immunoprecipitation studies, using total protein extracts of cells expressing tagged versions of DUX4 and GR, support that these proteins are physically associated. Our studies suggest that DUX4 could modulate gene expression by co-regulating the activity of hormone NRs. This is the first report highlighting a potential endocrine role for DUX4.

Source: FEBS Letters

DOI: 10.1002/1873-3468.14416

Authors: Julieta Quintero, Nizar Y. Saad, Sabrina M. Pagnoni, Daniela K. Jacquelin, Laura V. Gatica, Scott Q. Harper, Alberto L. Rosa

Institutions: Universidad Católica de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas, Nationwide Children's Hospital, Abigail Wexner Research Institute, The Ohio State University, Fundacion Allende

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Consejo Nacional de Investigaciones Científicas y Técnicas, Korea National Institute of Health, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Fondo para la Investigación Científica y Tecnológica

Awards: In vivo efficacy studies to support the development of DUX4-targeted RNAi therapy for FSHD, G2195126060, G4736560580, Biomarkers for Therapy of FSHD (U54), G671422757, G7217240261, Novel Therapeutics for FSHD

OpenAlex ID: W4281672959

FWCI: 1.076

Cites: 70

Cited by: 10

Related to: 10