Sweet Syndrome With Pulmonary Involvement Preceding the Development of Myelodysplastic Syndrome
Year: 2022
Type: article
Abstract: To the Editor: A 59-year-old man was referred to our clinic for a rash, fever, and night sweats following treatment for metastatic seminoma with cisplatin and etoposide.Physical examination revealed indurated erythematous papules and plaques on the trunk and upper and lower extremities, some with annular or arcuate configuration with trailing scale (Figure , A).A skin biopsy demonstrated mild papillary dermal edema with a mixed infiltrate of mononuclear cells, neutrophils, eosinophils, mast cells, lymphocytes, and karyorrhectic debris without evidence of leukocytoclastic vasculitis.The histopathologic differential diagnosis included a histiocytoid variant of Sweet syndrome (SS), and our patient's rapid clinical response to corticosteroids supported this diagnosis.With a relapsing and remitting course over 3 years, the rash eventually evolved into more edematous papules and plaques (Figure , B), and a repeat biopsy 3 years later
Source: Cutis
DOI: 10.12788/cutis.0547
Author: David Y. Chen
Institution: Washington University in St. Louis
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4281699782