Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition
Year: 2022
Type: article
Abstract: BACKGROUND & AIMS: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. METHODS: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in plasma phospholipid fraction and amino acids in blood were assessed. RESULTS: Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were associated with the corresponding fatty acids in plasma (partial-r = 0.24) or with intake of specific foods such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain amino acids (partial-r = 0.5). Intake of most other foods and of carnitine showed little association with AC levels. CONCLUSIONS: Our results show that determinants of ACs in blood vary according to their fatty acid moiety, and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential determinants may help interpret associations of ACs with disease risk and inform on potential dietary and lifestyle factors that might be modified for disease prevention.
Source: Clinical Nutrition
Authors: Roland Wedekind, Joseph A. Rothwell, Vivian Viallon, Pekka Keski-Rahkonen, Julie A. Schmidt, Veronique Chajes, Vna Katzke, Theron Johnson, Maria Santucci de Magistris, Vittorio Krogh, Pilar Amiano, Carlotta Sacerdote, Daniel Redondo-Sánchez, José María Huerta, Anne Tjønneland, Pratik Pokharel, Paula Jakszyn, Rosario Tumino, Eva Ardanaz, Torkjel M. Sandanger, Anna Winkvist, Johan Hultdin, Matthias B. Schulze, Elisabete Weiderpass, Marc J. Gunter, Inge Huybrechts, Augustin Scalbert
Institutions: Centre international de recherche sur le cancer, Inserm, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, University of Oxford, German Cancer Research Center, Federico II University Hospital, University of Naples Federico II, Fondazione IRCCS Istituto Nazionale dei Tumori, Basque Government, Biogipuzkoa Health Research Institute, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Instituto Murciano de Investigación Biosanitaria, University of Copenhagen, Danish Cancer Society, Edith Cowan University, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat Ramon Llull, Associazione Iblea per la Ricerca Epidemiologica E.T.S., Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, UiT The Arctic University of Norway, Umeå University, University of Potsdam, German Institute of Human Nutrition
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,100
Funders: World Health Organization, Deutsches Krebsforschungszentrum, World Cancer Research Fund International, Centres de Recerca de Catalunya, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Generalitat de Catalunya, Ligue Contre le Cancer, Vetenskapsrådet, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London
Awards: G1055973116, G1192877484, G1478484880, G172151099, G1767199718, G1878183890, G1993546569, G2027148636, G2131326840, G2235605558, G2409987178, G2539064604, G2572521044, G273148272, G2742323354, G2841678936, G2871896171, G29072894, G3010599472, G3049845011, G3077395769, G3138064951, G3189789075, G3216658785, G3328679326, G3544161537, G3747421453, G375319704, G382879149, G4041385912, G4089957676, G4213141252, G4303038735, G4473162978, Health of vegetarians, G459595259, G4844208673, G4879533352, G5004963360, G558017500, G5706284561, G5897142711, G5990830295, G6085534252, NIHR Senior Investigator Award, G6442500046, G6594529311, G6766485657, G6820515600, G7426181285, G7447125227, G7646326732, G7677770324, G8050896463, G817390530, G8279237360, G8508326818, G8846336397, G8959392569, G8978728421, G9000040826, G9000332718
OpenAlex ID: W4281705755