Year: 2022
Type: article
Abstract: Endothelial-to-mesenchymal transition (EndoMT) is the process of endothelial cells progressively losing endothelial-specific markers and gaining mesenchymal phenotypes. In the normal physiological condition, EndoMT plays a fundamental role in forming the cardiac valves of the developing heart. However, EndoMT contributes to the development of various cardiovascular diseases (CVD), such as atherosclerosis, valve diseases, fibrosis, and pulmonary arterial hypertension (PAH). Therefore, a deeper understanding of the cellular and molecular mechanisms underlying EndoMT in CVD should provide urgently needed insights into reversing this condition. This review summarizes a 30-year span of relevant literature, delineating the EndoMT process in particular, key signaling pathways, and the underlying regulatory networks involved in CVD.
Source: Cells
Authors: Qianman Peng, Dan Shan, Kui Cui, Kathryn Li, Bo Zhu, Hao Wu, Beibei Wang, Scott Wong, Vikram Norton, Yunzhou Dong, Yao Wei Lu, Changcheng Zhou, Hong Chen
Language: English
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,303
Awards: G1258888668, G1278793335, Endocrine disruptor mediated activation of PXR causes dyslipidemia and atherosclerosis, G1790241457, Mechanisms regulating VEGF receptors in diabetic angiogenesis, Molecular Regulation of Atherosclerosis, G419418261, G6307788311, G6312209985, Molecular Mechanisms Governing Vascular Cell Function and Phenotype in Health and Disease, G6900940596, G780364943, G9000023118, G9000035904, G9000071126, G9000121394, G9000171788, G9000206236, G9000281320, G95573990, G99573168
OpenAlex ID: W4281720842