Work

A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985

Year: 2022

Type: article

Abstract: This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.

Source: Phosphorus, sulfur, and silicon and the related elements

DOI: 10.1080/10426507.2022.2085272

Authors: Niccole Auld, Krystal Flood, Tanay Kesharwani, Peter J. Cavnar

Institution: University of West Florida

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of West Florida, National Institutes of Health, National Institute of General Medical Sciences