Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Head circumference is associated with intelligence and tracks from childhood into adulthood. METHODS: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. RESULTS: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. CONCLUSIONS: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
Source: BMC Medical Genomics
Authors: Suzanne Vogelezang, Jonathan P. Bradfield, Suzanne Vogelezang, Jonathan P. Bradfield, Stefan Johansson, Evie Stergiakouli, Elisabeth Thiering, Craig E. Pennell, Tarunveer S. Ahluwalia, Ville Karhunen, Markus Scholz, Xueping Liu, Carmen Iñiguez, Olli T. Raitakari, Jonas Bacelis, Theresia M. Schnurr, Timo A. Lakka, Ioanna Ntalla, Mads V. Lind, Lotte Lauritzen, Sauli Herrala, Frederick T. J. Lin, Christine Frithioff-Bøjsøe, Robin N. Beaumont, Mohammed H. Zafarmand, Peter Rzehak, Jose R. Bilbao, Nella Junna, Judith M. Vonk, Sheryl L. Rifas-Shiman, Vimala D. Janjanam, Maria J. Knol, Shweta Ramdas, Lawrie Beilin, Klaus Bønnelykke, Maribel Casas, Johan G. Eriksson, Joaquin Escribano, Tavia E. Evans, Ulrike Gehring, Frank Geller, Veit Grote, Darek Gruszfeld, Hakon Hakonarson, Andrew T. Hattersley, Christian T. Have, M. Geoffrey Hayes, Joachim Heinrich, Øvind Helgeland, Jhon Holloway, Raimo Joro, Julius Juodakis, Bridget A. Knight, Bert Koletzko, Antje Körner, Jean-Paul Langhendries, Jaakko T. Leinonen, Virpi Lindi, Morten A. V. Lund, Stephen Lye, Mads Melbye, Kim F. Michaelsen, Camilla S. Morgen, Harri Niinikoski, Katja Pahkala, Kalliope Panoutsopoulou, Oluf Pedersen, Fernando Rivadeneira, Loreto Santa-Marina, Barbera D. C. Schaik, Denise Scholtens, Sylvain Sebert, Ibon Tamayo, Nicholas J. Timpson, Maties Torrent, André G. Uitterlinden, Marc Vaudel, Elvira Verduci, Rebecca Vinding, Mandy Vogel, Eleftheria Zeggini, Christopher Brown, Hieab H. H. Adams, Wilfried Karmaus, Marie-France Hivert, Gerard H. Koppelman, Elisabeth Widén, Nora Fernandez-Jimenez, Melanie Waldenberger, Tanja G. M. Vrijkotte, Rachel M. Freathy, Jens-Christian Holm, William L. Lowe, Niels Grarup, Torben Hansen, George V. Dedoussis, Mustafa Atalay, Ellen A. Nohr, Bo Jacobsson, Niina Pitkänen, Martine Vrijheid, Bjarke Feenstra, Wieland Kiess, Marjo-Riita Jarvelin, Hans Bisgaard, Carol Wang C, Marie Standl, Mark I. McCarthy, Beate St Pourcain, Pål R. Njølstad, Struan F. A. Grant, Janine F. Felix, Vincent W. V. Jaddoe
Institutions: Erasmus MC, Children's Hospital of Philadelphia, Haukeland University Hospital, University of Bergen, University of Pennsylvania, University of Bristol, MRC Integrative Epidemiology Unit, Helmholtz Munich, Ludwig-Maximilians-Universität München, University of Copenhagen, Gentofte Hospital, Copenhagen Prospective Studies on Asthma in Childhood
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,790
Funders: American Diabetes Association, Simons Foundation, March of Dimes Foundation, Oak Foundation, Massachusetts General Hospital, Kaiser Permanente, Children's Hospital of Philadelphia, Mead Johnson Nutrition, University of Pennsylvania, Northwestern University, Västra Götalandsregionen, Foundation for Cardiovascular Research, Itä-Suomen Yliopisto, Stiftelsen Kristian Gerhard Jebsen, Helsingin Yliopisto, University of Notre Dame, Fundació la Marató de TV3, Suomen Lääketieteen Säätiö, Queen Mary University of London, Institut d'Investigació Sanitària Pere Virgili, Royal Devon and Exeter NHS Foundation Trust, Yrjö Jahnssonin Säätiö, Jalmari ja Rauha Ahokkaan Säätiö, Finska Läkaresällskapet, Wellcome Trust, University of Memphis, Università degli Studi di Milano, Royal College of Physicians of Edinburgh, Centres de Recerca de Catalunya, Australian Government, Cotswold Foundation, Universitat Pompeu Fabra, Amsterdam University Medical Centers, Cancer Research UK, National Institute for Health and Care Research, Diabetes UK, University of Exeter, University of Southampton, Imperial College London, University of Oxford, European Commission, University of Bristol, Raine Medical Research Foundation, Women and Infants Research Foundation, Deutsche Forschungsgemeinschaft, Rijksuniversiteit Groningen, Curtin University of Technology, Edith Cowan University, Murdoch University, University of Notre Dame Australia, ZonMw, Universiteit van Amsterdam, Erasmus Universiteit Rotterdam, Universiteit Utrecht, Radboud Universiteit, Kela, Academy of Finland, Generalitat de Catalunya, Gentofte Hospital, Erasmus Medisch Centrum, Eusko Jaurlaritza, Suomen Kulttuurirahasto, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Generalitat Valenciana, Euskal Herriko Unibertsitatea, Universitat de València, Juho Vainion Säätiö, Kuopion Yliopistollinen Sairaala, Max-Planck-Gesellschaft, Novo Nordisk, Päivikki ja Sakari Sohlbergin Säätiö, Signe ja Ane Gyllenbergin Säätiö, Universidad de Navarra, Emil Aaltosen Säätiö, Samfundet Folkhälsan, Helmholtz-Zentrum für Umweltforschung, Universitetet i Bergen, Universitair Medisch Centrum Groningen, National and Kapodistrian University of Athens, Norges Forskningsråd, Turun Yliopisto, Sydäntutkimussäätiö, Suomen Hammaslääkäriseura Apollonia, Technische Universität München, Ludwig-Maximilians-Universität München, Sahlgrenska Universitetssjukhuset, Göteborgs Universitet, Oulun Yliopisto, Syddansk Universitet, Bergens Forskningsstiftelse, Aarne ja Aili Turusen Säätiö, Universitat Rovira i Virgili, Paavo Nurmen Säätiö, Faculty of Health and Medical Sciences, University of Western Australia, Region Sjælland, Novo Nordisk Fonden, Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, Haukeland Universitetssjukehus, Government of Western Australia, Novo Nordisk Foundation Center for Basic Metabolic Research, Turun Yliopistollinen Keskussairaala, OLVI-Säätiö, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Terveyden ja hyvinvoinnin laitos, Freistaat Sachsen, Turun Yliopistosäätiö, Max Planck Instituut voor Psycholinguïstiek, National Institutes of Health, School of Medicine, Stanford University, Perelman School of Medicine, University of Pennsylvania, Feinberg School of Medicine, Horizon 2020 Framework Programme, Canadian Institutes of Health Research, Medical Research Council, National Health and Medical Research Council, Leibniz-Gemeinschaft, Jenny ja Antti Wihurin Rahasto, Instituto de Salud Carlos III, Pohjois-Savon Rahasto, Sahlgrenska Akademin, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet, European Regional Development Fund, Statens Serum Institut, Helmholtz Zentrum München, Klinisk Institut, Syddansk Universitet, NIHR Exeter Clinical Research Facility, Biocenter, University of Oulu, Norwegian Institute of Public Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development, European Social Fund
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OpenAlex ID: W4281774813