Impact of Hematopoietic Cell Transplantation on Cardiovascular Risk Factors and Insulin Resistance
Year: 2022
Type: preprint
Study design: Observational Study
Abstract: Cardiovascular Disease (CVD) contributes to the increased risk of non-relapse late mortality after hematopoietic cell transplant (HCT). HCT survivors have a higher risk for insulin resistance and adverse CVD risk factors but the impact of exposure to HCT preparative conditioning regimens has not been clearly delineated. We enrolled 151 HCT recipients (26.4 ±0.9 years; time since HCT of 2.6-31.5 years) and 92 sibling controls to complete a cardiovascular risk assessment including insulin sensitivity by hyperinsulinemic euglycemic clamp, anthropometry, body composition by dual X-ray absorptiometry, blood pressure, and serum biomarkers. We used linear models to test for mean differences in all continuous outcomes between survivors and siblings, accounting for intra-family correlations with generalized estimating equations. Recipients of HCT were found to have lower insulin sensitivity and more likely to have adverse CVD risk factors in comparison to their healthy siblings. Significantly higher percent fat mass and visceral adipose tissue, and significantly lower lean body mass were noted in HCT recipients than sibling controls despite having a similar body mass index between the two groups. Total body irradiation in the conditioning regimen was one of the strongest factors associated with lower insulin sensitivity, dyslipidemia and abnormal body composition leading to sarcopenic obesity.
Source: Research Square
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4281873586