Work

Pathogenesis of Alcohol-Associated Liver Disease

Year: 2022

Type: review

Abstract: Excessive alcohol consumption is a global healthcare problem with enormous social, economic, and clinical consequences. While chronic, heavy alcohol consumption causes structural damage and/or disrupts normal organ function in virtually every tissue of the body, the liver sustains the greatest damage. This is primarily because the liver is the first to see alcohol absorbed from the gastrointestinal tract via the portal circulation and second, because the liver is the principal site of ethanol metabolism. Alcohol-induced damage remains one of the most prevalent disorders of the liver and a leading cause of death or transplantation from liver disease. Despite extensive research on the pathophysiology of this disease, there are still no targeted therapies available. Given the multifactorial mechanisms for alcohol-associated liver disease pathogenesis, it is conceivable that a multitherapeutic regimen is needed to treat different stages in the spectrum of this disease.

Source: Journal of Clinical and Experimental Hepatology

DOI: 10.1016/j.jceh.2022.05.004

Authors: Natalia A. Osna, Karuna Rasineni, Murali Ganesan, Terrence M. Donohue, Kusum K. Kharbanda

Institutions: VA Nebraska Western Iowa Health Care System, University of Nebraska Medical Center

Language: English

Topic: Alcohol Consumption and Health Effects

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,150