Work

Editorial: Advances in CNS Repair, Regeneration, and Neuroplasticity: From Basic Mechanisms to Therapeutic Strategies

Year: 2022

Type: editorial

Abstract: StrategiesLoss of neural cells and neuronal networks in the CNS frequently results in permanent functional deficits with minimal recovery.Current treatments for patients suffering from neurological functional deficits are largely limited.Recent studies have provided insight into secondary injury mechanisms and signaling pathways for controlling CNS repair and regeneration.Researchers have identified new molecular and cellular targets and effective therapeutic strategies for promoting cell survival, CNS regeneration, neural circuit reconnections, remyelination, and neuroplasticity in adult CNS.This Research Topic focuses on recent preclinical research advances in CNS repair, regeneration, and neuroplasticity.We published 29 articles on this Research Topic, including 17 reviews and 12 original research articles.These studies targeted multiple molecular and cellular components using several model systems, including traumatic brain injury (TBI), spinal cord injury (SCI), optic nerve crush (ONC), neurodegeneration, and in vitro cell cultures.Many articles focused on enhancing viability of neural cells and regeneration, reconnection, and plasticity of injured CNS neurons by targeting diverse CNS pathophysiology, including inflammatory cascades and regeneration failure of axotomized CNS axons.

Source: Frontiers in Cellular Neuroscience

DOI: 10.3389/fncel.2022.898546

Author: Shuxin Li

Institution: Temple University

Language: English

Topic: Nerve injury and regeneration

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950