Work

Candida parapsilosis Mdr1B and Cdr1B Are Drivers of Mrr1-Mediated Clinical Fluconazole Resistance

Year: 2022

Type: article

Abstract: Candida parapsilosis is a common cause of invasive candidiasis worldwide and is the most commonly is7olated Candida species among pediatric and neonatal populations. Previous work has demonstrated that nonsynonymous mutations in the gene encoding the putative transcription factor CpMrr1 can influence fluconazole susceptibility. However, the direct contribution of these mutations and how they influence fluconazole resistance in clinical isolates are poorly understood.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00289-22

Authors: Laura A. Doorley, Jeffrey M. Rybak, Elizabeth L. Berkow, Qing Zhang, Joachim Morschhäuser, P. David Rogers

Institutions: St. Jude Children's Research Hospital, University of Tennessee Health Science Center, University of Würzburg

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases