Increased risk of incident knee osteoarthritis in those with greater work-related physical activity
Year: 2022
Type: article
Abstract: Objective Occupations involving greater physical activity may increase risk for knee osteoarthritis (OA). Existing studies have not evaluated work-related physical activity before OA onset. Hence, we aimed to evaluate the association between work-related physical activity and knee OA incidence. Methods We performed a person-based longitudinal study using Osteoarthritis Initiative (OAI) data among people who volunteered or worked for pay without baseline radiographic knee OA or knee pain. Bilateral knee radiographs were obtained at baseline and annual follow-ups. We defined radiographic OA as Kellgren-Lawrence grade ≥2. Questions from the Physical Activity Scale for the Elderly at baseline and annual OAI visits provided information about work-related physical activity level and hours. We performed logistic regression with work-related physical activity level (mainly sitting,standing and some walking,walking while handling some materials) and hours as predictors. The outcome was incident person-based radiographic OA within the ensuing 12 months, over 48 months. Results Among 951 participants (2819 observations), higher work-related physical activity levels had greater adjusted ORs for incident radiographic OA (people with jobs withstanding and some walking: 1.11 (0.60–2.08), andwalking while handling some materials: 1.90 (1.03–3.52), when compared with those withmainly sitting work-related activity). There was no association between number of hours worked and incident radiographic OA. Conclusions People performing work that require walking while handling some materials have greater odds of incident knee OA than those with jobs mostly involving sitting. Strategies are needed to mitigate risk factors predisposing them to radiographic OA.
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1843889331, Clinical Centers for the Osteoarthritis Initiative, Periarticular Bone Density as a Biomarker for Early Knee OA, G3049869442, G3111192696, G3363071810, G409491633, G4504702245, Data Coordinating Center for the Osteoarthritis Initiative, G4976748030, G511777355, Clinical Centers for the Osteoarthritis Initiative, G5230142545, G604760239, Clinical Centers for the Osteoarthritis Initiative^Rhode Island, Modifiable Risk Factors for Incident and Progressive Early Knee Osteoarthritis, Clinical Centers for the Osteoarthritis Initiative
OpenAlex ID: W4282917611
