Inspiratory rhythm generation is stabilized by Ih
Year: 2022
Type: article
Abstract: The Ih current plays multiple roles within the preBötC. This current is important for promoting intrinsic tonic spiking activity in excitatory and inhibitory neurons and for preserving rhythmic function during conditions that dampen network excitability, such as in the context of opioid-induced respiratory depression. We therefore propose that the Ih current expands the dynamic range of rhythmogenesis, buffers the preBötC against network perturbations, and stabilizes rhythmogenesis by preventing the generation of unsynchronized bursts.
Source: Journal of Neurophysiology
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: G1108851325, G18839183, Integrative Consequences of Hypoxia, G331183993, G3349763980, Rhythmogenic states of the respiratory network reveal differential opioid sensitivity, G3842654662, Homeostatic Plasticity of the Respiratory Rhythm Generating Network, Neuroglial interactions underlying the generation of the sigh, Integrative Consequences of Intermittent Hypoxia, Homeostatic Plasticity of the Respiratory Rhythm Generating Network, Unraveling the dynamic mechanisms underlying opioid respiratory depression, Unraveling respiratory rhythm generation in medullary and supramedullary networks
OpenAlex ID: W4282921115