Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders

Year: 2022

Type: article

Abstract: Despite its major role in complex human functions across the lifespan, most notably navigation, learning and memory, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 white British individuals, we reveal 177 unique genetic loci with distributed associations across the hippocampal formation. We identify genetic overlap with eight brain disorders with typical onset at different stages of life, where common genes suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.

Source: Nature Communications

DOI: 10.1038/s41467-022-31086-w

Authors: Shahram Bahrami, Kaja Nordengen, Alexey A. Shadrin, Oleksandr Frei, Dennis van der Meer, Anders M. Dale, Lars T. Westlye, Ole A. Andreassen, Tobias Kaufmann

Institutions: Oslo University Hospital, University of Oslo, Maastricht University, University of California San Diego, University of Tübingen

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,890

Funders: Stiftelsen Kristian Gerhard Jebsen, Universitetet i Oslo, Norges Forskningsråd, Nasjonalforeningen for Folkehelsen, Medical Research Council, Helse Sør-Øst RHF

OpenAlex ID: W4282926517