Work

Race against Time between the Virus and Host: Actin-Assisted Rapid Biogenesis of Replication Organelles is Used by TBSV to Limit the Recruitment of Cellular Restriction Factors

Year: 2022

Type: article

Abstract: Replication of positive-strand RNA viruses is affected by the recruitment of host components, which provide either proviral or antiviral functions during virus invasion of infected cells. The delivery of these host factors into the viral replication organelles (VROs), which represent the sites of viral RNA replication, depends on the cellular actin network. Using TBSV, we uncover a race between the virus and its host with the actin network as the central player. We find that in susceptible plants, tombusviruses exploit the actin network for rapid delivery of proviral host factors into VROs and ultimately overcome host restriction factors. In summary, this work demonstrates that the actin network plays a major role in determining the outcome of viral infections in plants.

Source: Journal of Virology

DOI: 10.1128/jvi.00168-21

Authors: Melissa Molho, Shifeng Zhu, Peter D. Nagy

Institution: University of Kentucky

Language: English

Topic: Plant Virus Research Studies

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institute of Food and Agriculture

Awards: G172309820, Key host factors co-opted to form viral replication organelles, The Cellular Actin Network and Virus Replication