Longitudinal Changes in Arterial Stiffness and Heart Rate Variability in Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study
Year: 2022
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: We compared arterial stiffness and heart rate variability (HRV) over time by diabetes type and determined the risk factors associated with worsening arterial stiffness and HRV in young adults with youth-onset diabetes. RESEARCH DESIGN AND METHODS: Arterial stiffness (pulse wave velocity, augmentation index) and six indices of heart rate variability were measured twice, 4.5 years apart, among participants with either youth-onset type 1 or type 2 diabetes in the SEARCH for Diabetes in Youth study. Multivariable linear regression models were used to assess risk factors associated with arterial stiffness and HRV at follow-up. RESULTS: Of 1,159 participants studied, 949 had type 1 diabetes (mean age 17.1 ± 4.7 years, 60.3% non-Hispanic White, 55% female) and 210 had type 2 diabetes (mean age 22.1 ± 3.5 years, 23.8% non-Hispanic White, 71% female) at initial assessment when diabetes duration was 7.9 years (both groups). Participants with type 2 versus type 1 diabetes had greater arterial stiffness and more abnormalities in HRV at initial and follow-up assessment and a greater change over time (all P < 0.05). Risk factors associated with worse arterial stiffness and HRV at follow-up in both types of diabetes included higher blood pressure, hemoglobin A1c, waist circumference, and triglycerides over time and longer diabetes duration. CONCLUSIONS: Arterial stiffness and HRV worsened over time with greater changes among participants with type 2 versus type 1 diabetes and among those with features of the metabolic syndrome. The risk factor profile documents potentially modifiable pathways to prevent or limit cardiovascular complications in young adults with youth-onset diabetes.
Source: Diabetes Care
DOI: 10.2337/dc21-2426
Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati, Wake Forest University Health Sciences, Wake Forest University, University of Colorado Anschutz, Centers for Disease Control and Prevention, University of North Carolina at Chapel Hill, Kaiser Permanente, University of Washington
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Veterans Affairs, Kaiser Permanente, Wake Forest University, Cincinnati Children's Hospital Medical Center, Seattle Children's Research Institute, Ohio Department of Health, National Institutes of Health, Centers for Disease Control and Prevention, University of North Carolina at Chapel Hill, University of Colorado Denver, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Chronic Disease Prevention and Health Promotion, National Center for Advancing Translational Sciences
Awards: G1002765518, G1016118505, G1061576540, G1085451520, G1092462818, G1095442109, G1146718029, G1244565456, G1318526806, G1377809435, G1433562272, G1460797131, SEARCH FOR DIABETES IN YOUTH PHASE 3: COHORT STUDY - CALIFORNIA CENTER, G1517268644, G1529905483, G155784727, G1615242365, G1662392790, G1679682984, G1711565907, G173331, G1819525783, G1862601839, G188050375, UCHSC Diabetes and Endocrinology Research Center, Colorado Clinical and Translational Science Institute (UL1), G1996657135, G204141994, G2044937890, SEARCH FOR DIABETES IN YOUTH REGISTRY STUDY, PHASE 4: CAROLINA CENTER (COMPONENT A), G2091809135, G2120788241, G2184972462, G22646245, G2295491902, G2302182590, G2320993242, G244787544, G2528023306, G2588769983, G2698360221, G2707946402, G2712579115, G2736310229, G2781854687, G2894014400, G2906879622, G3000326140, G3013847213, G3036940369, G3094316502, G3146357332, G3207814498, G3232449911, G327346145, G3340164175, G3394515489, SEARCH FOR DIABETES IN YOUTH REGISTRY STUDY, PHASE 4: OHIO CENTER, G3437629819, G3481391726, G3482807279, G3539854705, Institute of Translational Health Sciences, G3691635126, G3722324604, SEARCH FOR DIABETES IN YOUTH 3: WASHINGTON SITE PART B, G3818523422, G3837654701, G3861154396, G3869600316, G3913620056, SEARCH FOR DIABETES IN YOUTH REGISTRY STUDY, PHASE 4: WASHINGTON CENTER, G4035719383, South Carolina Clinical & Translational Research Institute (SCTR), G4086984516, G4105791890, G4150019378, G4169180449, G4186956826, G4221519001, G4282291616, G4312580361, THE SEARCH FOR DIABETES IN YOUTH REGISTRY STUDY, G4441617054, SEARCH FOR DIABETES IN YOUTH PHASE 3: COHORT STUDY-CAROLINA CENTER, G4572416490, G4579419327, G4590232811, G4618533316, G4669381972, G4753745396, G4757612579, G4780661971, G4808119738, Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort Study, G4860788691, G4890923187, G492257343, G4976965329, G5166157367, G5195453449, G5231222958, G5263611099, Center for Clinical and Translational Science and Training, G5273663056, G5291314479, G5316717321, G5324987677, G5364337274, G5386769879, G5401091, G5406584491, G5424006154, G5452025758, G5476724143, G5586995813, G5637679330, G5670778107, G5697510622, G5755860087, G5947551922, G5962293421, G600531474, G6029072327, G6070552965, G6072223391, G6089049465, G6120250853, G6198875767, G6254102176, G6315140273, G639100339, G6397790380, G6403799585, G6422816456, G6432626016, G6528713444, Limited Competition for the Closeout of the SEARCH for Diabetes in Youth Cohort Study, G6785625214, G6790387525, SEARCH FOR DIABETES IN YOUTH 2: CALIFORNIA CENTER, G6844501505, G6850813666, G6880221729, G6926053894, G6926574329, G6936333586, G6986679822, G6994813492, G7073940600, G7123860007, G7166520374, G7173154897, G7230772705, G7330461463, G7340126633, G7417637724, G7432750608, G7452318213, G7473609315, G7546995069, G7585356609, G7713430636, G7728521447, G7741199762, G7756189037, G7765907116, POPULATION-BASED DIABETES IN YOUTH REGISTRY. SEARCH FOR DIABETES IN YOUTH, PHASE 4, CALIFORNIA SITE, G77764702, G7859535267, G7887311335, G7887614091, G7897290752, G7943099461, G7943243696, G7948093198, G7966674055, G7986701142, G806184463, G8194560534, G821340895, G821379033, G8216919925, South Carolina Clinical & Translational Research Institute (SCTR), G8305844340, G832786732, G8354842452, G8357409503, G8365049767, G8436394025, G8469119123, G847497056, G8612043118, G8637021020, G8676770334, Cincinnati Center for Clinical and Translational Sciences and Training, G8725321909, G873585168, G874743574, G8767603179, G8887544645, G8924043061
OpenAlex ID: W4282942533