Work

Genome Wide Association Studies of Variant-by-Thiazide Interaction on Lipids Identifies a Novel Low-Density Lipoprotein Cholesterol Locus

Year: 2022

Type: article

Abstract: Although thiazide diuretics are common therapies for the treatment of high blood pressure, they are also associated with elevated blood lipid concentrations after initiation. Total cholesterol concentrations have been shown to increase by 4%, low-density lipoprotein cholesterol (LDL-C) concentrations by 10%, and triglyceride (TG) concentrations by 5% to 15%; high density lipoprotein cholesterol concentrations remain unaffected. Pharmacogenomics could potentially help identify mechanistic pathways underlying this observation. However, few well-powered studies examining variant-by-thiazide interactions on blood lipid concentrations have been conducted. The purpose of this study was to identify genetic variants that modify the effect of thiazide diuretics on LDL-C, total cholesterol, and TG using data from the UK Biobank (UKBB), a publicly available, longitudinal study of UK adults.

Source: Circulation Research

DOI: 10.1161/circresaha.122.321120