Work

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain

Year: 2022

Type: article

Abstract: opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons. However, opioid receptor-mediated regulation of neuronal function and synaptic transmission is not uniform in expression pattern and mechanism across the brain. The localization of receptors within specific cell types and neurocircuits determine the effects that endogenous and exogenous opioids have on brain function. In this review we will explore the similarities and differences in opioid receptor-mediated regulation of neurotransmission across different brain regions. We discuss how future studies can consider potential cell-type, regional, and neural pathway-specific effects of opioid receptors in order to better understand how opioid receptors modulate brain function.

Source: Frontiers in Molecular Neuroscience

DOI: 10.3389/fnmol.2022.919773

Authors: Kaitlin C. Reeves, Nikhil Shah, Braulio Muñoz, Brady K. Atwood

Institutions: Medical University of South Carolina, Indiana University School of Medicine

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950