Work

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

Year: 2022

Type: review

Abstract: gene display improved neurobehavioral deficits, reduced neuropathology, and amelioration of neuronal cell death and inflammatory biomarkers. The significance of the compelling CTSB evidence is that the data consilience validates CTSB as a drug target for discovery of CTSB inhibitors as potential therapeutics for treating numerous neurological diseases.

Source: Pharmacological Reviews

DOI: 10.1124/pharmrev.121.000527

Authors: Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark Kindy, Christoph Peters, Vivian Hook

Institutions: Beijing Institute of Technology, University of Freiburg, German Cancer Research Center, Deutsches Konsortium für Translationale Krebsforschung

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: U.S. Department of Veterans Affairs, Deutsche Forschungsgemeinschaft, Deutschen Konsortium für Translationale Krebsforschung, National Institutes of Health, Japan Society for the Promotion of Science, National Institute of Neurological Disorders and Stroke

Awards: G105579614, Development of Molecular Probe Inhibitors of Pathogenic, Cytosolic Cathespin B in Traumatic Brain Injury and Alzheimers Disease Neurodegeneration, G2234928323, Elucidating new mechanism of brain barrier-synaptic disruptions caused by P. gingivitis, Cathepsin B inhibitor Drug Development for Traumatic Brain Injury, G6296468327, GRK 2606: Entschlüsselung zellulärer Proteasefunktionen durch Identifizierung und Analyse von Proteasesubstraten (ProtPath), Elucidation of Alzheimer's disease exacerbation mechanism of periodontitis centering on microglia-related neuroinflammation, G912826795, G913599493

OpenAlex ID: W4282983570

FWCI: 2.348

Cites: 290

Cited by: 94

Related to: 10