Year: 2022
Type: review
Abstract: Apicomplexan parasites have complex metabolic networks that coordinate acquisition of metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has a wide host range and may rely on the flexibility of this metabolic network. Currently, the literature categorizes genes as essential or dispensable according to their dispensability for parasite survival under nutrient-replete in vitro conditions. However, recent studies revealed correlations between medium composition and gene essentiality. Therefore, nutrient availability in the host environment likely determines the requirement of metabolic pathways, which may redefine priorities for drug target identification in a clinical setting. Here we review the recent work characterizing some of the major Toxoplasma metabolic pathways and their functional adaptation to host nutrient content.
Source: Trends in Parasitology
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $6,700
Awards: Redox regulation of protein functions in the plastid of Toxoplasma gondii, G2331484096, Elucidating the metabolic and lipidic adaptation of Toxoplasma gondii towards its human host nutritional environment, G2618575860, Alliance française contre les maladies parasitaires, G6747919083, G8486087644, Lost in translation. Dissecting the divergent features of Toxoplasma gondii mitochondrial translation
OpenAlex ID: W4283014853