Work

Rise of the Clones: Myelodysplastic Syndrome to Secondary Acute Myeloid Leukemia

Year: 2022

Type: article

Abstract: Summary: Myelodysplastic syndrome (MDS) describes a family of blood disorders driven by the clonal expansion of mutated blood cells that can evolve into secondary acute myeloid leukemia (sAML). Two new studies use single-cell and deep sequencing to elucidate the progression of MDS to AML, revealing discrete clonal architectures and the driving role of signaling mutations. See related article by Guess et al., p. 316 (8) . See related article by Menssen et al., p. 330 (9) .

Source: Blood Cancer Discovery

DOI: 10.1158/2643-3230.bcd-22-0046

Authors: Kyle A. Romine, Peter van Galen

Institutions: Oregon Health & Science University, Brigham and Women's Hospital

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4283025107