Work

Emerging ENDS products and challenges in tobacco control toxicity research

Year: 2022

Type: article

Abstract: Electronic nicotine delivery systems (ENDS) continue to rapidly evolve. Current products pose unique challenges and opportunities for researchers and regulators. This commentary aims to highlight research gaps, particularly in toxicity research, and provide guidance on priority research questions for the tobacco regulatory community. Disposable flavoured ENDS have become the most popular device class among youth and may contain higher nicotine levels than JUUL devices. They also exhibit enhanced harmful and potentially harmful constituents production, contain elevated levels of synthetic coolants and pose environmental concerns. Synthetic nicotine and flavour capsules are innovations that have recently enabled the circumvention of Food and Drug Administration oversight. Coil-less ENDS offer the promise of delivering fewer toxicants due to the absence of heating coils, but initial studies show that these products exhibit similar toxicological profiles compared with JUULs. Each of these topic areas requires further research to understand and mitigate their impact on human health, especially their risks to young users.

Source: Tobacco Control

DOI: 10.1136/tobaccocontrol-2022-057268

Authors: Robert M Strongin, Eva Sharma, Hanno C Erythropel, Ahmad El-Hellani, Nada O F Kassem, Vladimir B Mikheev, Alexandra Noël, David H Peyton, Matthew L Springer

Institutions: Portland State University, Westat (United States), Yale University, Virginia Commonwealth University, The Ohio State University, San Diego State University, Battelle, Louisiana State University, University of California, San Francisco

Language: English

Topic: Smoking Behavior and Cessation

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Institute of Environmental Health Sciences, Center for Tobacco Products

Awards: G1388174528, Integrated Health, Behavioral and Economic Research on Current and Emerging Tobacco Products, G2561858819, G3299515750, Integrated risk assessment and molecular characterization of pulmonary response to e-cigarette exposure, Center for the Study of Tobacco Products, G4205287274, Effect of third-generation electronic cigarettes design features on aerosol constituents and pulmonary toxicity in vitro and in vivo, G6276530786, Toxicant Production and Mitigation in the Electronic-Cigarette Reaction Vessel, G7855619483, G8811392208, Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP), Center for Coordination of Analysis, Science, Enhancement, and Logistics (CASEL) in Tobacco Regulatory Science, G927571801, G962442201

OpenAlex ID: W4283030223

FWCI: 1.811

Cites: 60

Cited by: 13

Related to: 10