OpenAlex | Association of High Tumor Mutation Burden in Non–Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels

Association of High Tumor Mutation Burden in Non–Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels

Work

Year: 2022

Type: article

Abstract: Importance Although tumor mutation burden (TMB) has been explored as a potential biomarker of immunotherapy efficacy in solid tumors, there still is a lack of consensus about the optimal TMB threshold... more

Source: JAMA Oncology

Authors Biagio Ricciuti, Xinan Wang, Joao V. Alessi, Hira Rizvi, Navin R. Mahadevan +33 more

Institutions Dana-Farber Cancer Institute, Harvard University, Memorial Sloan Kettering Cancer Center, Cornell University, Brigham and Women's Hospital +8 more

Cites: 28

Cited by: 226

Related to: 10

FWCI: 37.52

Citation percentile (by year/subfield): 100

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Sustainable Development Goal Reduced inequalities

Open Access status: hybrid