Year: 2022
Type: article
Abstract: Ion channels are fundamental biological devices that act as gates in order to ensure selective ion transport across cellular membranes; their operation constitutes the molecular mechanism through which basic biological functions, such as nerve signal transmission and muscle contraction, are carried out. Here, we review recent results in the field of computational research on ion channels, covering theoretical advances, state-of-the-art simulation approaches, and frontline modeling techniques. We also report on few selected applications of continuum and atomistic methods to characterize the mechanisms of permeation, selectivity, and gating in biological and model channels.
Source: Advances in Physics X
Institutions: Sapienza University of Rome, Istituto Nazionale di Fisica Nucleare, Institute for Complex Systems, Istituto Nazionale di Fisica Nucleare, Sezione di Roma I, Università Campus Bio-Medico, University of Palermo, Forschungszentrum Jülich, Helmholtz Institute Erlangen-Nürnberg, Marche Polytechnic University, Italian Institute of Technology, Rice University, Roma Tre University, University of Cagliari, Australian National University, University of Tübingen, University of Chicago
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,895
Awards: G1123282263, G434337789, G4437196451, Ionic Coulomb blockade oscillations and the physical origins of permeation, selectivity, and their mutation transformations in biological ion channels, G4987307311, Computational Studies of Ion Channels, Ionic Coulomb blockade oscillations and the physical origins of permeation, selectivity, and their mutation transformations in biological ion channels, G8710648302, G892375944, G9000262743, G9000320561
OpenAlex ID: W4283079448