Work

Mitochondria transplantation/transfer between single cells

Year: 2022

Type: editorial

Abstract: Mitochondrial transplantation/transfer has been increasingly recognized as a potential way for cell and tissue revitalization. In a recent study, Gabelein et al. reported a novel method for single cells mitochondria transplantation using "nanosyringe". This technique combines atomic force microscopy, optical microscopy, and nanofluidics that enable intra- and intercellular organelle micromanipulation and cell-to-cell mitochondria transplantation with up to 95% success rate. The transferred mitochondria fuse to the host mitochondrial network and donor mtDNA incorporate into the recipient mitochondrial genome. The nanosyringe technique provides a novel tool for future mitochondrial research to offer insight into mitochondrial replacement therapy for stroke and fundamental mitochondrial biology.

Source: Journal of Cerebral Blood Flow & Metabolism

DOI: 10.1177/0271678x221109685

Authors: Qin Hu, Jianfei Lu, Xiaohua Zhang, Ran Liu, Shao-Hua Yang

Institutions: Shanghai Jiao Tong University, Renji Hospital, University of North Texas Health Science Center

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke