Work

Protocol for three alternative paradigms to test spatial learning and memory in mice

Year: 2022

Type: article

Abstract: Here, we describe three alternative paradigms to overcome the limitations of the most widely used spatial learning paradigm for rodents: the Morris water maze. We outline the preparation of behavioral testing rooms and mouse handling/habituation prior to testing. We then detail three spatial learning and memory tasks: the Barnes maze, active place avoidance, and novel object location tasks. These tests have been successfully used across multiple ages (from 2 to 24 months) in both wild-type and transgenic animals. For complete details on the use and execution of this protocol, please refer to Leiter et al. (2022).

Source: STAR Protocols

DOI: 10.1016/j.xpro.2022.101500

Authors: Daniel G. Blackmore, David Brici, Tara L. Walker

Institution: The University of Queensland

Language: English

Topic: Memory and Neural Mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,500

Funders: Wilson Foundation, Queensland Brain Institute