Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. METHODS: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression. RESULTS: During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively). CONCLUSIONS: The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.
Source: BMC Cancer
Authors: Katharina Nimptsch, Krasimira Aleksandrova, Veronika Fedirko, Mazda Jenab, Marc J. Gunter, Peter D. Siersema, Kana Wu, Verena Katzke, Rudolf Kaaks, Salvatore Panico, Domenico Palli, Anne M May, Sabina Sieri, Bas Bueno-de-Mesquita, Karina Standahl, Maria-Jose Sánchez, Aurora Perez-Cornago, Anja Olsen, Anne Tjønneland, Catalina Bonet Bonet, Christina C. Dahm, María-Dolores Chirlaque, Valentina Fiano, Rosario Tumino, Aurelio Barricarte Gurrea, Marie-Christine Boutron-Ruault, Florence Menegaux, Gianluca Severi, Bethany van Guelpen, Young-Ae Lee, Tobias Pischon
Institutions: Harvard University, Max Delbrück Center, University of Bremen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, The University of Texas MD Anderson Cancer Center, Emory University, Centre international de recherche sur le cancer, Radboud University Nijmegen, Radboud University Medical Center, German Cancer Research Center, Federico II University Hospital, University of Naples Federico II, Utrecht University, University Medical Center Utrecht, Fondazione IRCCS Istituto Nazionale dei Tumori, National Institute for Public Health and the Environment, UiT The Arctic University of Norway, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, University of Oxford, Aarhus University, Danish Cancer Society, University of Copenhagen, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, University of Turin, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Centre de recherche en Epidémiologie et Santé des Populations, University of Florence, Umeå University, Charité – Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,790
Funders: World Health Organization, Cancer Prevention and Research Institute of Texas, Universitetet i Tromsø, Deutsches Krebsforschungszentrum, European Association of Social Psychology, Cancer Research UK, National Institute for Health and Care Research, University of Cambridge, Imperial College London, University of Oxford, Institut National de la Santé et de la Recherche Médicale, Universiteit Utrecht, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Vetenskapsrådet, Università degli Studi di Firenze, Umeå Universitet, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Universidad de Granada, Università degli Studi di Torino, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Université de Versailles Saint-Quentin-en-Yvelines, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London, Wallenberg Centre for Molecular and Translational Medicine
Awards: Aetiology of type 2 diabetes and related metabolic disorders, G1192877484, G2185877915, G2714613917, G3328679326, G3376064638, G4079049029, G423933611, G4289084031, G4378152838, G4409035895, G4495613716, Health of vegetarians, G4844208673, G493358262, The EPIC-Norfolk prospective population study: biological and behavioural determinants of health and disease in an ageing population, G4968824801, G5078184151, G5116888081, G5315906942, Recruitment of Rising Stars, G5851461211, G6085534252, G6089501056, G6324679927, G6376359690, G6594529311, G6870695443, G6883270616, G6923329853, G6957242214, G7677770324, G7987655622, G8020903098, G8139206928, G8377080268, G8544555571, G8914830642, G896962615, G899966268, G928779021
OpenAlex ID: W4283378556