Work

Treatment of Depression with Botulinum Toxin

Year: 2022

Type: article

Abstract: Injection of botulinum toxin (BoNT) into the glabellar region of the face is a novel therapeutic approach in the treatment of depression. This treatment method has several advantages, including few side effects and a long-lasting, depot-like effect. Here we review the clinical and experimental evidence for the antidepressant effect of BoNT injections as well as the theoretical background and possible mechanisms of action. Moreover, we provide practical instructions for the safe and effective application of BoNT in the treatment of depression. Finally, we describe the current status of the clinical development of BoNT as an antidepressant and give an outlook on its potential future role in the management of mental disorders.

Source: Toxins

DOI: 10.3390/toxins14060383

Authors: Marc Axel Wollmer, Michelle Magid, Tillmann H. C. Kruger, Eric Finzi

Institutions: Asklepios, Asklepios Kliniken Hamburg, The University of Texas at Austin, Medizinische Hochschule Hannover, George Washington University

Language: English

Topic: Botulinum Toxin and Related Neurological Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,513