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BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis

Year: 2022
Type: article
Abstract: The intestinal immune system and microbiota are emerging as important contributors to the development of metabolic syndrome, but the role of intestinal dendritic cells (DCs) in this context is incompletely understood. BATF3 is a transcription factor essential in the development of mucosal conventional DCs type 1 (cDC1). We show that Batf3-/- mice developed metabolic syndrome and have altered localization of tight junction proteins in intestinal epithelial cells leading to increased intestinal permeability. Treatment with the glycolysis inhibitor 2-deoxy-D-glucose reduced intestinal inflammation and restored barrier function in obese Batf3-/- mice. High-fat diet further enhanced the metabolic phenotype and susceptibility to dextran sulfate sodium colitis in Batf3-/- mice. Antibiotic treatment of Batf3-/- mice prevented metabolic syndrome and impaired intestinal barrier function. Batf3-/- mice have altered IgA-coating of fecal bacteria and displayed microbial dysbiosis marked by decreased obesity protective Akkermansia muciniphila, and Bifidobacterium. Thus, BATF3 protects against metabolic syndrome and preserves intestinal epithelial barrier by maintaining beneficial microbiota.
DOI: 10.3389/fimmu.2022.841065
Authors: Hussein Hamade, Jasmine T. Stamps, Dalton T. Stamps, Shyam K. More, Lisa S. Thomas, Anna Y. Blackwood, Nawele L. Lahcene, Sofi L. Castanon, Brenda C. Salumbides, Yosuke Shimodaira, Helen S. Goodridge, Stephan R. Targan, Kathrin S. Michelsen
Language: English
Open Access status: gold
Estimated APC paid: $2,950
Funders: Crohn's and Colitis Foundation of America, Crohn's and Colitis Foundation, Cedars-Sinai Medical Center, Sorbonne Université, University of California, San Diego, National Institute of Diabetes and Digestive and Kidney Diseases
OpenAlex ID: W4283398856
FWCI: 0.49
Cites: 101
Cited by: 7
Related to: 10