Year: 2022
Type: article
Abstract: Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. Other evidence supports that ferroptosis is participated osteoporotic bone remodeling, predominantly affecting the interaction between bone formation and bone resorption, explicitly bone resorption exceeded bone formation. Based on previous studies, this review will summarize the regulatory network mechanism of ferroptosis on bone remodeling and reveal the role of ferroptosis in osteoporosis (OP).
Source: Frontiers in Public Health
Authors: Chunlu Yan, Jinlong Zhang, Fangyu An, Jiayu Wang, Yao Shi, Lingqing Yuan, Donghui Lv, Yanzhen Zhao, Yongfeng Wang
Institution: Gansu University of Traditional Chinese Medicine
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Awards: G1245520461, G4011822936
OpenAlex ID: W4283792520