LOXL-2 and TNC-C Are Markers of Liver Fibrogenesis in HCV/HIV-, HIV- and HCV-Infected Patients
Year: 2022
Type: article
Study design: Observational Study
Abstract: Background: Lysil oxidase like enzyme-2 (LOXL-2) and TNC-C play important roles in organ fibrosis. We assessed circulating LOXL-2 and TNC-C levels and their relationship to fibrosis severity in HIV- and/or HCV-infected individuals. Methods: Healthy controls (n = 22), HIV mono- (n = 15), HCV mono- (n = 52) and HCV/HIV-co-infected (n = 92) subjects were included. Results: LOXL-2 and TNC-C levels were significantly higher in HCV mono- and HCV/HIV-co-infected individuals with F0 compared to healthy controls. In addition, in HCV/HIV-co-infected individuals, LOXL-2 levels were higher in intermediate fibrosis compared to no/mild fibrosis. Conclusion: In HCV/HIV-co-infected study participants, both LOXL-2 and TNC-C were significantly higher in intermediate fibrosis compared to no/mild fibrosis, but did not further increase with advanced fibrosis. Furthermore, both markers were elevated among HCV/HIV-positive individuals with mild/no fibrosis.
Source: Biomarkers in Medicine
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Foundation for the National Institutes of Health, Gladstone Institutes, ACT Government, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, National Institutes of Health, University of California, San Francisco, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Center for AIDS Research, University of California, San Diego
Awards: G1050281965, G1531094742, G1819583291, G2582431053, G2821729970, G2839755957, G285461174, G3118978292, G3181090803, G3810609436, G3917235369, G4394150684, G4553935269, G4727913932, G4882740767, G5076517209, G550251769, G7628721337, G857487509, G9000039438, G9000047228, G9000078127, G9000081321, G9000100957, G9000182931, G9000292181, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, CFAR Network of Integrated Clinical Systems (CNICS), AIDS Clinical Trial Group Laboratory Center, Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG), University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit, G97119092
OpenAlex ID: W4283812127